The tachykinin receptor 3 gene has been linked to alcohol and cocaine dependence

• The search for genes associated with alcohol dependence (AD) has recently been extended to the tachykinin receptor 3 gene (TACR3), located within a broad region on chromosome 4q.
• Researchers have found that seven of the nine single nucleotide polymorphisms – DNA sequence variations – in the 3’ region of TACR3 have a significant association with AD as well as cocaine dependence.

Previous family-based research had linked a broad region on chromosome 4q with alcohol dependence (AD). A new study has found that nine of the single nucleotide polymorphisms (SNPs) – DNA sequence variations – in the 3’ region of the tachykinin receptor 3 gene (TACR3), located within chromosome 4q, have a significant association with AD, particularly those with more severe AD, and co-existing cocaine dependence. … Continue Reading »